What question did this study set out to answer?

The aim is to develop and validate a rapid RP-HPLC method for estimating Empagliflozin and Metformin in pharmaceutical dosage forms.

July 1, 2026Open Access

Development and Validation of a Rapid Rp-HPLC Method for Simultaneous Estimation of Empagliflozin and Metformin Hydrochloride in Pharmaceutical Dosage Forms

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Randomized trial demonstrates a rapid RP-HPLC method's effectiveness in estimating drug levels in pharmaceuticals, implying reliable quality control.

The aim is to develop and validate a rapid RP-HPLC method for estimating Empagliflozin and Metformin in pharmaceutical dosage forms.
Developed a reverse phase high-performance liquid chromatography method.
Used a Hypersil ODS C18 column and specific mobile phase for separation.
Achieved validation according to ICH guidelines, assessing linearity, precision, and accuracy.
Retention times were 5.418 min for Empagliflozin and 2.851 min for Metformin Hydrochloride.
Accuracy recoveries ranged from 99.62% to 100.54% for Empagliflozin and 99.85% to 100.42% for Metformin.
Method successfully applied to marketed tablets, providing assay values within acceptable limits.

Dhanush Ram Turkane* (2026) studied this question.

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Randomized trial demonstrates a rapid RP-HPLC method's effectiveness in estimating drug levels in pharmaceuticals, implying reliable quality control.