February 1, 1990Circulation
Mildly dilated congestive cardiomyopathy. Use of prospective diagnostic criteria and description of the clinical course without heart transplantation.
Why the study?
Does heart transplantation improve survival compared to medical therapy in patients with mildly dilated congestive cardiomyopathy?
Population
20 patients with mildly dilated congestive cardiomyopathy, defined as end-stage heart failure of unknown…
Comparison
Heart transplantation vs Medical therapy (nontransplant)
Design
Cohort
Follow-up
20 +/- 8 months
Authors
Discussion
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Member takes
Implication
May support transplantation in persistent MDCM; leaves open need for randomized confirmation of survival benefit.
Structured PICO
Does heart transplantation improve survival compared to medical therapy in patients with mildly dilated congestive cardiomyopathy?
P
Population
20 patients with mildly dilated congestive cardiomyopathy (MDCM), defined as end-stage heart failure of unknown etiology (NYHA class IV, LVEF < 30%) without typical restrictive hemodynamics or significant ventricular dilatation (<15% above normal range).
I
Intervention
Heart transplantation
C
Comparator
Medical therapy (nontransplant)
O
Outcome
Total survivalhard clinical
Heart transplantation significantly improves survival in patients with mildly dilated congestive cardiomyopathy who have persistent severe cardiac dysfunction despite medical therapy.
Cite This Study
Keren et al. (1990) studied this question.