Population
Cultured bovine aortic endothelial cells and microvessels isolated from Zucker lean rats and…
Comparison
Insulin (10 to 10 mmol/L) with or without PI-3… vs Untreated cells/microvessels; Zucker lean vs…
Design
Preclinical
Follow-up
2 to 8 hours of incubation
Authors
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May explain endothelial dysfunction in insulin resistance; leaves open whether PI-3 kinase modulation improves vascular outcomes.
Insulin regulates eNOS gene expression via PI-3 kinase activation, a pathway that is impaired by PKC activation in states of insulin resistance.
Kuboki et al. (2000) studied this question.
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