Key result
Physical training increases circulating EPCs ~180% vs control in mice and stable CAD patients.
Why the study?
The molecular mechanisms by which physical training improves peripheral and coronary artery disease are poorly understood, particularly regarding endothelial progenitor cells.
Does physical training increase circulating endothelial progenitor cells and enhance angiogenesis in mice and patients with stable coronary artery disease?
RCT (n=19)
randomized
Does physical training increase circulating endothelial progenitor cells and enhance angiogenesis in mice and patients with stable coronary artery disease?
Physical activity increases circulating endothelial progenitor cells and enhances angiogenesis via a partially NO-dependent mechanism, providing a molecular basis for the cardiovascular benefits of exercise.
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Moderate exercise may raise EPCs in stable CAD; leaves open clinical outcome benefits pending randomized trials.
Laufs et al. (2003) conducted an RCT in stable coronary artery disease (n=19). Physical training vs. No exercise / controls was evaluated on Numbers of circulating endothelial progenitor cells (EPCs). Physical training significantly increased circulating endothelial progenitor cells to 280% of control levels at 28 days in mice, and similarly increased EPCs in patients with stable CAD.
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