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October 2, 2002JAMA

Exercise training improves endothelial vasodilator function and left ventricular diastolic function in patients with type 2 diabetes and hypertension, despite a lack of large randomized trials.

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Why the study?

Does exercise training improve cardiovascular health in persons with type 2 diabetes and hypertension?

Population

Persons with type 2 diabetes and hypertension

Design

Review

Key result

Exercise training improves endothelial vasodilator function and left ventricular diastolic function in patients with type 2 diabetes and hypertension, despite a lack of large randomized trials.

Authors

KSKerry J. Stewart

Discussion

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Member takes

Overview

May support exercise training for endothelial and LV diastolic benefits in type 2 diabetes with hypertension; leaves open large RCTs.

Key Points

  • This review aims to evaluate the effects of exercise training on cardiovascular health in individuals with type 2 diabetes and hypertension.
  • Conducted a MEDLINE search from January 1985 to June 2002 and reviewed bibliographies from relevant articles.
  • Considered meta-analyses, smaller trials, nonrandomized trials, and animal studies due to limited large randomized trials.
  • Assessed data quality based on publication in peer-reviewed journals or professional society literature.
  • Exercise training significantly improves endothelial vasodilator function and left ventricular diastolic function.
  • Evidence for benefits on arterial stiffness and systemic inflammation is weaker but not disproven.
  • Changes in body composition through exercise training lead to improved insulin sensitivity and blood pressure.

Structured PICO

Does exercise training improve cardiovascular health in persons with type 2 diabetes and hypertension?

P
Population
Persons with type 2 diabetes and hypertension
I
Intervention
Exercise training
O
Outcome
Cardiovascular health parameters including endothelial vasodilator function, left ventricular diastolic function, arterial stiffness, systemic inflammation, and left ventricular masssurrogate

Exercise training provides cardiovascular benefits beyond glycemic control and blood pressure reduction in patients with type 2 diabetes and hypertension, particularly by improving endothelial and left ventricular diastolic function.

Limitations

  • Lack of large randomized controlled trials
  • few large, randomized trials exist on these topics

Cite This Study

Kerry J. Stewart (2002) conducted a review in Type 2 diabetes and hypertension. Exercise training was evaluated. Exercise training improves endothelial vasodilator function and left ventricular diastolic function in patients with type 2 diabetes and hypertension, despite a lack of large randomized trials.

synapsesocial.com/papers/6a0513ff6c3d07813971bceahttps://doi.org/10.1001/jama.288.13.1622
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