Population
HCN2 pacemaker channels (in vitro model)
Comparison
Alanine-scanning mutagenesis of the HCN2 S4-S5… vs Wild-type HCN2 channels
Design
Preclinical
Authors
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Does not alter arrhythmia management; hypothesis-generating for HCN-targeted therapies in preclinical models.
The S4-S5 linker in HCN pacemaker channels is crucial for coupling voltage sensing to channel activation, functioning as a gate near the inner pore.
Chen et al. (2001) studied this question.
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