January 20, 2004CirculationOpen Access

Atrial Extracellular Matrix Remodeling and the Maintenance of Atrial Fibrillation

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Population

n=69 tissue samples, including 53 explanted hearts from patients with dilated cardiomyopathy and end-stage…

Design

Cross-sectional

Authors

JXJun XuUniversity of South China GCGuanggen CuiUCLA Medical Center FEF. EsmailianCedars-Sinai Medical Center

Discussion

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Implication

Links atrial matrix remodeling to sustained AF in HF; leaves open whether MMP-2/TIMP-2 modulation affects outcomes.

Structured PICO

Population

n=69 tissue samples, including 53 explanted hearts from patients with dilated cardiomyopathy and end-stage heart failure who underwent heart transplantation (19 permanent AF, 18 persistent AF, 16 no documented AF) and 16 donor left atria as controls.

Comparator

Donor left atria (controls) and patients with no documented AF

Outcome

Atrial extracellular matrix components including TIMP-2, MMP-2, and type I collagen volume fraction (CVF-I)surrogate

Atrial extracellular matrix remodeling, characterized by TIMP-2 downregulation and MMP-2/CVF-I upregulation, is associated with sustained atrial fibrillation in heart failure patients.

Cite This Study

Xu et al. (2004) studied this question.

synapsesocial.com/papers/69f53fcae0fbb6efbd203bbe https://doi.org/10.1161/01.cir.0000109495.02213.52

Topics

Atrial fibrillation Persistent AF management

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Atrial Extracellular Matrix Remodeling and the Maintenance of Atrial Fibrillation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Atrial Extracellular Matrix Remodeling and the Maintenance of Atrial Fibrillation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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