Regulation of Angiotensin II Receptor Subtypes During Atrial Fibrillation in Humans
Key result
AF is linked to downregulated atrial AT1-R and a ~505% increase in AT2-R proteins.
- P<0.01
- n=30
Why the study?
It was unknown whether the expression of atrial angiotensin II receptor subtypes changes during atrial fibrillation in humans.
Does atrial fibrillation alter the expression of angiotensin II receptors in human atrial tissue compared to sinus rhythm?
Population
30 patients undergoing open heart surgery including 11 with chronic persistent AF, 8 with paroxysmal AF, and 11 in sinus rhythm
Comparison
Patients with chronic persistent or paroxysmal AF vs patients in sinus rhythm
Design
Cross-sectional analysis of atrial tissue samples
Authors
Discussion
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Implication
AF may involve angiotensin receptor shifts in atrial remodeling; hypothesis-generating and should not yet change practice.
Study Design
Type
Observational (n=30)
Structured PICO
Does atrial fibrillation alter the expression of angiotensin II receptors in human atrial tissue compared to sinus rhythm?
P
Population
30 patients undergoing open heart surgery, including 11 with chronic persistent AF, 8 with paroxysmal AF, and 11 in sinus rhythm.
C
Comparator
Patients in sinus rhythm
O
Outcome
Atrial expression of angiotensin II type 1 and type 2 receptors (AT1-R and AT2-R) at protein and mRNA levelssurrogate
Main Result
p-value: p=<0.01
Atrial fibrillation is associated with the down-regulation of atrial AT1-R and up-regulation of AT2-R proteins, suggesting a pathophysiological role of the angiotensin system in atrial structural remodeling.
Cite This Study
Goette et al. (2000) conducted an observational in Atrial fibrillation (n=30). Atrial fibrillation vs. Sinus rhythm was evaluated on Atrial expression of angiotensin II type 1 and type 2 receptors (p=<0.01). Atrial fibrillation was associated with downregulation of atrial AT1-R (reduced to 34.9% in chronic AF, P<0.01) and upregulation of AT2-R proteins (increased 505% in paroxysmal AF, P<0.01).