Key result
AT1 receptor density was selectively downregulated in failing human left ventricles compared to nonfailing ventricles (3.20 vs 4.66 fmol/mg protein), with a greater decrease in idiopathic dilated cardiomyopathy.
Authors
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No immediate change to HF therapy; extends beta-1 downregulation observations but leaves clinical translation open.
Observational (n=71)
Absolute Event Rate: 3.2% vs 4.66%
Asano et al. (1997) conducted an observational in Chronically failing human ventricular myocardium (n=71). Failing human ventricular myocardium vs. Nonfailing human ventricular myocardium was evaluated on AT1 receptor density (fmol/mg protein). AT1 receptor density was selectively downregulated in failing human left ventricles compared to nonfailing ventricles (3.20 vs 4.66 fmol/mg protein), with a greater decrease in idiopathic dilated cardiomyopathy.
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