What does this research mean for the field?

AT1-receptor gene expression is 2.5-fold greater in nonfailing hearts compared to failing human ventricles, whereas AT2 expression is unaffected. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

This research aims to investigate the expression levels of AT1 and AT2 angiotensin receptors in failing vs. non-failing hearts.

March 4, 1997Circulation

AT1and AT2Angiotensin Receptor Gene Expression in Human Heart Failure

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Heart failure (n=21). Intervention: Failing ventricular myocardium vs. Nonfailing donor hearts. Primary outcome: Expression of AT1 and AT2 subtypes of the angiotensin II receptor mRNA (2.5-fold greater in nonfailing, p=0.015).

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Key result

AT1-receptor gene expression was 2.5-fold greater in nonfailing hearts compared to failing human ventricles (P=0.015), whereas AT2 expression was unaffected.

Authors

GHGuy A. HaywoodUniversity Hospitals Plymouth NHS Trust LGLars GullestadHeart Failure & Transplant TKTomohiro KatsuyaGeneral / Preventive / Lipids

Discussion

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Implication

Does not warrant changes to ARB use in HF; extends prior observations on ventricular AT1 expression.

Key Points

This research aims to investigate the expression levels of AT1 and AT2 angiotensin receptors in failing vs. non-failing hearts.
Analyzed ventricular myocardium from 9 non-failing donor hearts and 12 failing patient hearts.
Used competitive reverse transcription-polymerase chain reaction to detect and quantify mRNA.
Compared expression levels of AT1 and AT2 receptors between groups.
AT1 receptor gene expression was 2.5-fold greater in non-failing hearts (P=0.015).
No significant difference in AT2 receptor mRNA expression between failing and non-failing hearts.

Study Design

Type

Observational (n=21)

PICO

Population

Heart failure (n=21)

Intervention / Comparator

Failing ventricular myocardium vs Nonfailing donor hearts

Primary Outcome

Expression of AT1 and AT2 subtypes of the angiotensin II receptor mRNA — 2.5-fold greater in nonfailing, p=0.015

Main Result

Effect estimate: 2.5-fold greater in nonfailing

p-value: p=0.015

Cite This Study

Haywood et al. (1997) conducted an observational in Heart failure (n=21). Failing ventricular myocardium vs. Nonfailing donor hearts was evaluated on Expression of AT1 and AT2 subtypes of the angiotensin II receptor mRNA (2.5-fold greater in nonfailing, p=0.015). AT1-receptor gene expression was 2.5-fold greater in nonfailing hearts compared to failing human ventricles (P=0.015), whereas AT2 expression was unaffected.

synapsesocial.com/papers/6a15984779ff98d0de4edcdb https://doi.org/10.1161/01.cir.95.5.1201

Topics

Heart transplantation Heart failure HFrEF treatment

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AT1and AT2Angiotensin Receptor Gene Expression in Human Heart Failure

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Main Result

Cite This Study

Topics

AT1and AT2Angiotensin Receptor Gene Expression in Human Heart Failure

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Main Result

Cite This Study

Also Consider

Topics

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