Population
12 patients with severe congestive heart failure and 5 age-matched healthy subjects undergoing vastus…
Design
Cross-sectional
Authors
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AT2-R absence in adult skeletal muscle suggests ARBs act via AT1-R alone in CHF; leaves open its role in other tissues or states.
The AT2-R gene is not expressed in the skeletal muscle of patients with severe CHF, suggesting the AT2-R pathway does not contribute to the vascular effects of AT1-R antagonists in this population.
Malendowicz et al. (2000) studied this question.
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