Key result
Heart failure patients with dilated cardiomyopathy had a 68% decrease in right ventricular AT1 mRNA content compared to controls (94 vs 297 copies/ng RNA; P<0.001).
Why the study?
Is AT1 ventricular mRNA content reduced in right ventricular endomyocardial biopsies from patients with heart failure compared to controls?
Population
28 patients undergoing right ventricular endomyocardial biopsy, including 16 with decreased left ventricular…
Design
Case-control
Authors
Loading...
May underlie reduced AT1 protein in HF; hypothesis-generating, should not change practice.
Observational (n=28)
Is AT1 ventricular mRNA content reduced in right ventricular endomyocardial biopsies from patients with heart failure compared to controls?
Effect estimate: 68% decrease
Absolute Event Rate: 94% vs 297%
p-value: p=<0.001
Ventricular AT1 mRNA is significantly downregulated in human heart failure, which may underlie the previously described decrease in AT1 protein expression.
Vera Regitz‐Zagrosek (1997) conducted an observational in Heart failure (dilated cardiomyopathy) (n=28). Heart failure (DCM) vs. Controls (normal cardiac function) was evaluated on AT1 mRNA content in right ventricular endomyocardial biopsies (copies/ng RNA) (68% decrease, p=<0.001). Heart failure patients with dilated cardiomyopathy had a 68% decrease in right ventricular AT1 mRNA content compared to controls (94 vs 297 copies/ng RNA; P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: