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May 2, 2026European Heart JournalOpen Access

Mortality from all causes and from coronary heart disease related to smoking and changes in smoking during a 35-year follow-up of middle-aged Finnish men

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Key result

Current smoking linked to ~62% higher 35-year all-cause mortality vs. non-smoking.

  • HR 1.62
  • 95% CI 1.40-1.88
  • n=1,711

Why the study?

Does smoking increase the risk of all-cause and coronary heart disease mortality in middle-aged men over a 35-year follow-up?

Population

1,711 middle-aged Finnish men born between 1900 and 1919, recruited in 1959

Comparison

Current smoking and former smoking vs Non-smokers

Design

Cohort

Follow-up

35 years

Authors

QQQing QiaoSir Run Run Shaw Hospital

Discussion

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Implication

Persistent smoking significantly increases the risk of premature death from all causes and coronary heart disease, while quitting smoking mitigates this risk to levels comparable to non-smokers.

Study Design

Type

Cohort (n=1,711)

Structured PICO

Does smoking increase the risk of all-cause and coronary heart disease mortality in middle-aged men over a 35-year follow-up?

P
Population
1,711 Finnish men born between 1900 and 1919, followed for 35 years to assess the effect of smoking on mortality.
E
Exposure
Current smoking and former smoking
C
Comparator
Non-smokers
O
Outcome
35-year all-cause mortality and 35-year coronary heart disease mortalityhard clinical

Main Result

Hazard Ratio: 1.62 (95% CI 1.4–1.88)

Persistent smoking significantly increases the risk of premature death from all causes and coronary heart disease, while quitting smoking mitigates this risk to levels comparable to non-smokers.

Cite This Study

Qing Qiao (2000) reported a cohort. Smoking vs. Non-smokers was evaluated on 35-year all-cause mortality (HR 1.62, 95% CI 1.40-1.88). Current smoking increased the risk of 35-year all-cause mortality compared with non-smokers (HR 1.62; 95% CI 1.40-1.88) among middle-aged Finnish men.

synapsesocial.com/papers/69f56d269954c85918edcb31https://doi.org/10.1053/euhj.2000.2151
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Smoking Cessation in Relation to Total Mortality Rates in Women: A Prospective Cohort Study1993 · 273 citations
  2. 2Predicting Coronary Heart Disease in Middle-Aged and Older Persons1977 · 234 citations
  3. 3LEVELS OF SOME BIOLOGICAL RISK INDICATORS AMONG ELDERLY MEN IN FINLAND1986 · 25 citations
  4. 4Cigarette smoking and health.1985 · 163 citations