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Model demonstrates transition from independent to collective neuron activity in cultures depending on calcium levels, implying important implications for understanding neuronal behavior.
We have developed a model able to describe the experimentally observed activity behavior of 2D neuronal cultures as the coupling between neurons varies. As [Ca2+] in the medium increases, a gradual transition occurs from an asynchronous state in which neurons behave as independent oscillators, to a synchronous state where bursts of collective activity appear.
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Monceau et al. (2026) studied this question.
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