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Synapse
May 4, 2026SHILAP Revista de lepidopterología0 citationsOpen Access

Synchronization in neuronal cultures

PMPascal MonceauSMStéphane MétensSBSamuel Bottani

Key Points

  • To model the activity behavior of 2D neuronal cultures as neuron coupling changes with varying calcium levels.
  • Developed a model to describe neuronal activity.
  • Examined the transition from asynchronous to synchronous activity based on varying calcium concentrations.
  • Analyzed how changes in calcium levels impact neuronal coupling.
  • Increased calcium levels lead to a transition from asynchronous to synchronous neuronal activity.
  • Neurons initially functioned as independent oscillators before forming collective bursts.
  • Observed a clear relationship between calcium concentration and neuronal synchronization.

Abstract

We have developed a model able to describe the experimentally observed activity behavior of 2D neuronal cultures as the coupling between neurons varies. As Ca 2+ in the medium increases, a gradual transition occurs from an asynchronous state in which neurons behave as independent oscillators, to a synchronous state where bursts of collective activity appear.

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Cite This Study

Monceau et al. (2026) studied this question.

synapsesocial.com/papers/69f836aa3ed186a739980e55https://doi.org/10.1051/epjconf/202636601010
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