Low serum testosterone levels are associated with increased risk of mortality in a population-based cohort of men aged 20-79
Key result
Low serum testosterone is linked to ~132% higher all-cause mortality in men.
- HR 2.32
- 95% CI 1.38-3.89
- n=1,954
Why the study?
Does low serum testosterone increase the risk of all-cause and cause-specific mortality in men aged 20-79?
Population
1954 men aged 20-79 from the prospective population-based Study of Health in Pomerania
Comparison
Low serum testosterone level vs Higher serum testosterone levels (≥8.7 nmol/L)
Design
Cohort
Follow-up
average 7.2 years
Authors
Discussion
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Implication
Low serum testosterone levels are an independent predictor of increased all-cause and cardiovascular mortality in adult men.
Study Design
Type
Cohort (n=1,954)
Structured PICO
Does low serum testosterone increase the risk of all-cause and cause-specific mortality in men aged 20-79?
P
Population
1,954 men aged 20-79 from a prospective population-based cohort, followed for an average of 7.2 years to assess mortality.
E
Exposure
Low serum testosterone level (<8.7 nmol/L or 250 ng/dL)
C
Comparator
Higher serum testosterone levels (≥8.7 nmol/L)
O
Outcome
All-cause mortalityhard clinical
Main Result
Hazard Ratio: 2.32 (95% CI 1.38–3.89)
Low serum testosterone levels are an independent predictor of increased all-cause and cardiovascular mortality in adult men.
Cite This Study
Haring et al. (2010) conducted a cohort in General population (n=1,954). Low serum testosterone levels (<8.7 nmol/L) vs. Higher serum testosterone levels was evaluated on All-cause mortality (HR 2.32, 95% CI 1.38-3.89). Low serum testosterone levels (<8.7 nmol/L) were associated with an increased risk of all-cause mortality in men aged 20-79 (adjusted HR 2.32; 95% CI 1.38-3.89).