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Directed viral egress promotes cell-to-cell spread in tissues; leaves open targeted antiviral strategies in solid organs.
Direct cell-to-cell spread of animal viruses in solid tissues is a complex, poorly understood process. A number of viruses have become very adept at moving from an infected cell to an adjoining uninfected cell, specifically at sites of cell-cell contact, moving across epithelial cell or neuronal
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Johnson et al. (2002) studied this question.
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