Why the study?
Understanding epithelial polarization is essential for a clear understanding of virus pathophysiology, as epithelial cells are targets for infectious agents.
Understanding epithelial polarization and the vectorial release of RNA viruses is essential for understanding virus pathophysiology.
Apical release dominates mucosal RNA virus exit; leaves open whether targeting basolateral trafficking limits systemic spread.
Epithelial cells are apico-basolateral polarized cells that line all tubular organs and are often targets for infectious agents. This review focuses on the release of human RNA virus particles from both sides of polarized human cells grown on transwells. Most viruses that infect the mucosa leave their host cells mainly via the apical side while basolateral release is linked to virus propagation within the host. Viruses do this by hijacking the cellular factors involved in polarization and trafficking. Thus, understanding epithelial polarization is essential for a clear understanding of virus pathophysiology.
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Chapuy‐Regaud et al. (2022) studied this question.
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