November 3, 1998Circulation
Cellular Basis for the Normal T Wave and the Electrocardiographic Manifestations of the Long-QT Syndrome
Why the study?
Does the transmural dispersion of repolarization determine the morphology of the T wave and the electrocardiographic manifestations of long-QT syndrome in a canine LV wedge model?
Population
Arterially perfused canine left ventricular (LV) wedge preparation
Comparison
Long-QT conditions vs Baseline conditions
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May inform T-wave interpretation in experimental long-QT; leaves open human validation of M-cell gradients.
Structured PICO
Does the transmural dispersion of repolarization determine the morphology of the T wave and the electrocardiographic manifestations of long-QT syndrome in a canine LV wedge model?
P
Population
Arterially perfused canine left ventricular (LV) wedge preparation
I
Intervention
Long-QT (LQT) conditions (including use of dl-sotalol)
C
Comparator
Baseline conditions
O
Outcome
Cellular transmembrane action potentials and transmural ECG events (T wave morphology, QT interval, Tpeak-Tend interval)surrogate
This study provides direct evidence that transmural dispersion of repolarization, specifically involving M cells, determines the normal T wave and the widened or bifurcated T waves (often mislabeled as U waves) seen in long-QT syndrome.
Cite This Study
Yan et al. (1998) studied this question.