Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death
Why the study?
Although echocardiographic LV hypertrophy is linked to all-cause and cardiovascular mortality, little was known regarding its association with sudden death.
Does increased left ventricular mass and hypertrophy increase the risk of sudden death in adults >=40 years of age?
Population
3,661 Framingham Heart Study subjects aged > or =40 years
Comparison
LV mass and LV hypertrophy vs without LV hypertrophy
Design
Prospective cohort study
Follow-up
Up to 14 years
Authors
Discussion
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Member takes
Implication
May enhance sudden death risk stratification via echo LV mass; leaves open whether LVH regression prevents events.
Structured PICO
Does increased left ventricular mass and hypertrophy increase the risk of sudden death in adults >=40 years of age?
P
Population
3,661 subjects enrolled in the Framingham Heart Study who were >=40 years of age
I
Intervention
Echocardiographically determined left ventricular (LV) mass and hypertrophy (defined as LV mass adjusted for height > 143 g/m in men and > 102 g/m in women)
C
Comparator
Subjects without left ventricular hypertrophy or with lower left ventricular mass
O
Outcome
Incidence of sudden death during up to 14 years of follow-uphard clinical
Echocardiographic left ventricular hypertrophy is associated with a more than twofold increased risk of sudden death, independent of known risk factors.
Cite This Study
Haider et al. (1998) studied this question.