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May 3, 2026

Chemical proteomics reveals sinomenine's anti-inflammatory mechanism through serum protein covalent modification.

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Authors

柳柳美先Macau University of Science and TechnologyZZZhiyuan ZhengMacau University of Science and TechnologyYZYida ZhangMacau University of Science and Technology

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Implication

Randomized trial investigates sinomenine's effects on inflammatory pathways, indicating new therapeutic potential.

Key Points

  • This research aims to elucidate the anti-inflammatory mechanisms of sinomenine through covalent protein modification.
  • Employed a chemical proteomics approach to evaluate sinomenine's modification potential.
  • Conducted in vivo serum proteomics analysis in rats to identify modified proteins.
  • Used bioinformatics for pathway enrichment and validated findings with western blotting.
  • Sinomenine modified cysteine and lysine residues via three distinct patterns.
  • Identified seven proteins modified by sinomenine, predominantly implicated in coagulation and complement pathways.
  • Sinomenine treatment significantly suppressed activation of the coagulation cascade and complement system.

Cite This Study

柳美先 et al. (2026) studied this question.

synapsesocial.com/papers/69f6e5618071d4f1bdfc61ddhttps://doi.org/10.1186/s13020-026-01403-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular mechanisms of the anti-inflammatory effect of sinomenine on atopic dermatitis2018
  2. 2Integrated Network Pharmacology, Molecular Docking, and Experimental Validation to Explore Potential Mechanisms of Sinomenine in the Treatment of Osteoarthritis2024 · 1 citations
  3. 3Research, Development and Pharmacological Activity of Sinomenine and Its Derivatives2024 · 7 citations
  4. 4Specific inhibition of glutamine synthase involved in the metabolic pathway of amino acids is associated with anti-arthritic effects of sinomenine hydrochloride2025 · 3 citations
  5. 5Sinomenine ameliorates rheumatoid arthritis in rodent models: a systematic review and meta-analysis of anti-inflammatory and joint-protective effects2026