What question did this study set out to answer?

The study aims to compare bronchoalveolar lavage cellular profiles across interstitial lung diseases stratified by fibrosis status.

May 3, 2026

Patterns of bronchoalveolar lavage in fibrotic and non-fibrotic interstitial lung diseases - a multicenter analysis.

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Retrospective multicenter study compares BAL cellular profiles in ILDs based on fibrosis, indicating limited utility in fibrotic cases.

The study aims to compare bronchoalveolar lavage cellular profiles across interstitial lung diseases stratified by fibrosis status.
Retrospective multicenter study of consecutive patients who underwent bronchoscopy with BAL for ILD evaluation from 2017 to 2022.
Chest radiologists conducted blinded radiological assessments and ILD diagnoses were assigned by a multidisciplinary team.
In total, 238 patients were included, of which 50.4% had fibrotic ILD.
BAL lymphocytes > 20% were present in 36.4% of non-fibrotic ILD patients versus 17.5% in fibrotic ILD (p < 0.01).
Lymphocyte counts were lower in fibrotic disease (β=-6.15, p = 0.007).
Honeycombing in CT scans was linked to lower rates of elevated BAL neutrophils (> 4.5%) in fibrotic cases (71% vs. 91%, p = 0.018).

Gershman et al. (2026) studied this question.

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