Mechanochemical NH4Cl-Mediated Hydrogen-Bonding Network Reconstruction of HFIP: Enabling Yne-Allylic Substitutions

Linhong Zuo; Haifeng Zhou; Qianzhi Yang; Xuguang Kong; Xin Liu; Qixing Liu

doi:10.1039/d6cc01632d

January 1, 2026Chemical Communications

Mechanochemical NH4Cl-Mediated Hydrogen-Bonding Network Reconstruction of HFIP: Enabling Yne-Allylic Substitutions

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Key Points

The aim is to explore a strategy for reconstructing hydrogen-bonding networks in HFIP using NH4Cl to enable yne-allylic substitutions.
Utilized NH4Cl in a mechanochemical setup to recombine hydrogen-bonding networks in HFIP.
Conducted mechanistic studies to clarify the operation's efficiency and effectiveness.
Investigated various substrates for diverse yne-allylic substitutions.
Successfully reconstructed the hydrogen-bonding network in HFIP, enhancing substitution efficiency.
Demonstrated an increase in the variety of yne-allylic substitutions facilitated by the NH4Cl method.
Achieved improved reaction conditions and outcomes compared to traditional methods.

Implication

Demonstrates yne-allylic substitutions in HFIP, suggesting a new method for chemical synthesis.

Abstract

Herein, we report a practical strategy for H-bonding network recombination of Hexafluoroisopropanol (HFIP) enabled by NH4Cl mediated mechanochemical operation, which efficiently facilitates diverse intermolecular yne-allylic substitutions. Mechanistic studies reveal the...

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Cite This Study

Zuo et al. (2026) studied this question.

synapsesocial.com/papers/69f6e5868071d4f1bdfc6356 https://doi.org/10.1039/d6cc01632d

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Mechanochemical NH4Cl-Mediated Hydrogen-Bonding Network Reconstruction of HFIP: Enabling Yne-Allylic Substitutions

Key Points

Implication

Abstract

Discussion

Cite This Study

Mechanochemical NH4Cl-Mediated Hydrogen-Bonding Network Reconstruction of HFIP: Enabling Yne-Allylic Substitutions

Key Points

Implication

Abstract

Discussion

Cite This Study

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