Randomized trial compares wrinkle reduction in healthy adults using two microneedling devices, suggesting effectiveness of temperature-controlled treatment.
Background Various devices are used for facial wrinkle treatment, but comparative data on their efficacy and safety are limited. Objective To compare the efficacy and safety of a temperature‐controlled bipolar fractional radiofrequency microneedling device (Profound) with a skin treatment system (EndyMed Pro) for facial wrinkle treatment. Methods A prospective, randomized controlled trial was conducted at three sites in China from February 2022 to May 2023. A total of 140 healthy adults (age ≥ 20, Fitzpatrick skin Type III–IV) were randomized to receive either a single Profound treatment or three EndyMed Pro treatments. Results No significant differences in wrinkle scores (Fitzpatrick, crow’s feet, and nasolabial folds) were observed between the two groups at 24 weeks. However, Profound showed superior results for wrinkles at the corner of the lips and the mandibular margin at 20 and 24 weeks ( p < 0.05). Conclusion Profound provided similar or superior improvements in wrinkle reduction compared to EndyMed Pro, particularly for wrinkles at the corner of the lips and the mandibular margin. Trial Registration: Chinese Registry of Clinical Trials: ChiCTR2200057102
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