Key result
High-output heart failure across all ages remains difficult to diagnose and can evade standard TTE.
Why the study?
High-output heart failure presents with common symptoms but is difficult to diagnose, as standard evaluations like transthoracic echocardiography may miss it.
High-output heart failure can present from the neonatal period to adulthood and may be missed by standard transthoracic echocardiography.
Maintain high suspicion for high-output HF despite normal standard TTE; leaves open need for prospective studies on diagnosis across ages.
High-output heart failure is an entity with a very common presenting symptom, yet difficult to diagnose, as the evaluation, including a standard transthoracic echocardiography, might miss the diagnosis. We describe a case series of individuals with high-output cardiac failure, spanning from neonatal to adult presentation.
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Parachikkottil et al. (2026) studied this question. High-output heart failure is a difficult-to-diagnose condition across all age groups that may be missed by standard evaluations, including transthoracic echocardiography.
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