Demonstrates the impact of heart orientation on hypoxemia in patients with PFO, suggesting closure may improve symptoms.
Altered cardiac orientation in the presence of a patent foramen ovale (PFO) can contribute to platypnea-orthodeoxia syndrome (POS) and unexplained hypoxemia. In such cases, consideration of PFO closure may lead to significant clinical improvement.
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Keisham et al. (2026) studied this question.
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