What question did this study set out to answer?

To understand the mechanism of platypnea-orthodeoxia syndrome associated with patent foramen ovale.

April 25, 2026Journal of the Society for Cardiovascular Angiography & Interventions0 citationsOpen Access

OR2-33 | Understanding a Mechanism of Platypnea Orthodeoxia Syndrome in Patients with a PFO

FEFrancisco X. Elisarraras FNFahed NegmeldinUniversity of California, Los Angeles MTMichael Tanoue

Key Points

To understand the mechanism of platypnea-orthodeoxia syndrome associated with patent foramen ovale.
Hypothesized that upright position increases PFO height
Examined shunting variations based on body position
Proposed mechanism involves increased right-to-left shunt in upright position
Orthodeoxia improves with recumbency, suggesting positional dependence

Abstract

Platypnea-orthodeoxia syndrome (POS) is a cause of positional dyspnea and hypoxemia that worsens in the upright position and improves with recumbency. It is proposed that the mechanism is due to increased right-to-left shunting, commonly through a patent foramen ovale (PFO). We hypothesized that the upright position leads to an increase in the PFO height facilitating orthodeoxia.

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Cite This Study

Elisarraras et al. (Wed,) studied this question.

synapsesocial.com/papers/69ec5aa788ba6daa22dac365 https://doi.org/https://doi.org/10.1016/j.jscai.2026.104467

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