Platypnea orthodeoxia syndrome should be considered in patients presenting with positional hypoxia, as early intervention can provide rapid symptomatic improvement.
Platypnea orthodeoxia syndrome (POS) is an uncommon phenomenon characterized by dyspnea and arterial desaturation in an upright position improved with recumbency. It is due to an anatomical factor that allows for interatrial communication and a functional factor that promotes right to left shunting. Once identified, early intervention allows for rapid symptomatic improvement. This case highlights that among patients who present with positional hypoxia, POS should be considered as a possible etiology. Thorough evaluation is warranted to identify potentially reversible etiologies and guide management.
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Agdamag et al. (2018) studied Atrial Septal Defect Presenting as Platypnea-Orthodeoxia Syndrome.
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