What question did this study set out to answer?

The aim is to address the challenges of diagnosing and managing oxygen-refractory platypnea-orthodeoxia syndrome.

May 31, 2026JACC Case Reports0 citationsOpen Access

Oxygen-Refractory Platypnea-Orthodeoxia Syndrome Requiring Urgent Surgical Closure

SSShota ShimizuShizuoka Red Cross Hospital SKShigetaka KageyamaInterventional Cardiology NTNaoyuki TakahashiShizuoka Red Cross Hospital

Key Points

The aim is to address the challenges of diagnosing and managing oxygen-refractory platypnea-orthodeoxia syndrome.
Urgent surgical intervention was employed to correct the right-to-left shunt.
Evaluation of posture-dependent hypoxemia was conducted to determine the severity of the condition.
Post-surgical assessment showed significant improvement in oxygen saturation levels.
Patient outcomes indicated resolution of posture-dependent hypoxemia.

Abstract

Platypnea-orthodeoxia syndrome (POS) causes posture-dependent hypoxemia due to right-to-left shunt, and it may be underestimated by routine evaluation.

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