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The study investigates the effect of perianal lidocaine application on patient comfort during unsedated colonoscopy.

May 3, 2026

Perianal lidocaine application during unsedated colonoscopy: A double-blind randomized controlled trial.

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The study investigates the effect of perianal lidocaine application on patient comfort during unsedated colonoscopy.
Randomized controlled trial with 122 patients aged 18-40 years.
Participants received either 2% lidocaine or normal saline around the anus during colonoscopy.
Main outcomes measured included anal pain, abdominal pain, cecal intubation time, and polyp detection rates.
Lidocaine group had significantly lower anal pain scores during and after colonoscopy (P < 0.001).
Lower abdominal pain scores after the procedure in lidocaine group compared to saline group (P < 0.001).
Higher polyp and adenoma detection rates noted in the lidocaine group (P < 0.05).

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Randomized trial examines lidocaine efficacy in reducing discomfort in adults undergoing unsedated colonoscopy, suggesting improved outcomes.

Wang et al. (2026) studied this question.

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Randomized trial examines lidocaine efficacy in reducing discomfort in adults undergoing unsedated colonoscopy, suggesting improved outcomes.