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This research investigates the role of secreted phospholipase PLA2G5 in hemolysis during sepsis.

May 3, 2026

Secreted phospholipase PLA2G5 acts as a hemolytic factor in sepsis.

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Randomized trial uncovers PLA2G5's role in hemolysis during sepsis, suggesting therapeutic potential.

This research investigates the role of secreted phospholipase PLA2G5 in hemolysis during sepsis.
Measured gene expression changes in colon cell types during sepsis.
Examined effects of genetic deletion of Pla2g5 and treatment with a PLA2G5 antibody.
Analyzed serum levels of PLA2G5 in humans with sepsis.
Genetic deletion of Pla2g5 and PLA2G5 antibody treatment improved outcomes in lethal sepsis.
PLA2G5 antibody treatment resulted in increased splenic red pulp macrophages (p<0.05) and improved iron homeostasis.
Elevated serum levels of PLA2G5 were predictive of disease severity and mortality in human sepsis.

Takahama et al. (2026) studied this question.

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