What question did this study set out to answer?

To review cancer- and cancer therapy-associated cardiovascular complications, including hypertension, arrhythmias, pericardial disease, and radiation-induced cardiotoxicity.

May 3, 2026Journal of the American College of Cardiology

Cardiovascular Complications of Cancer Therapy

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Why the study?

Caring for cancer patients with heart problems caused by cancer or cancer therapy presents clinical challenges, requiring cardiologists to become familiar with this emerging subspecialty.

Design

Literature review

Authors

HCHui‐Ming ChangTufts University TOTochukwu OkwuosaCardio-Oncology TSTiziano M. ScarabelliCollege of the Holy Cross

Discussion

Member takes

Implication

Supports heightened vigilance for CV side effects of targeted cancer therapies; leaves open optimal mitigation strategies pending dedicated trials.

Key Points

To review cancer- and cancer therapy-associated cardiovascular complications, including hypertension, arrhythmias, pericardial disease, and radiation-induced cardiotoxicity.
Conducted a comprehensive MEDLINE database search of published clinical data.
Synthesized recommendations from established clinical guidelines and institutional best practices across major cancer centers.
Targeted cancer therapies exhibit off-target cardiovascular effects, leading to systemic and pulmonary hypertension, thromboembolism, QT prolongation, and atrial fibrillation.
Radiation therapy accelerates atherosclerosis and induces progressive, long-term damage to the pericardium, cardiac valves, and electrical conduction system that can manifest years after exposure.

Cite This Study

Chang et al. (2017) studied this question.

synapsesocial.com/papers/69f7bbbef24b3d6ce8a680de https://doi.org/10.1016/j.jacc.2017.09.1095

Topics

Cardio-oncology

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Implication

Supports heightened vigilance for CV side effects of targeted cancer therapies; leaves open optimal mitigation strategies pending dedicated trials.

Cardiovascular Complications of Cancer Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Topics

Cardiovascular Complications of Cancer Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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Topics

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