Why the study?
Does intima-media thickness (IMT) of the internal carotid artery correlate better with prevalent coronary heart disease and atherosclerotic disease than common carotid artery IMT in older adults?
Population
5117 adults aged 65 years or more enrolled in the Cardiovascular Health Study
Design
Cross-sectional
Authors
Discussion
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Implication
ICA IMT associates more strongly with prevalent CHD and ASD than CCA IMT; hypothesis-generating for risk stratification and should not yet change practice.
Key Points
- The study aimed to investigate the relationship between carotid wall thickness and clinically manifest atherosclerotic disease in older adults.
- Measured intima-media thickness (IMT) using duplex ultrasound in 5117 participants from the Cardiovascular Health Study.
- Collected data on histories of coronary heart disease (CHD) and peripheral arterial disease during the baseline examination.
- Analyzed relationships using multiple regression and logistic regression to predict prevalent CHD and atherosclerotic disease based on IMT.
- IMT in carotid arteries was greater in those with CHD and atherosclerotic disease compared to those without (P < .001).
- IMT was higher in internal carotid arteries (ICA) than in common carotid arteries (CCA).
- ICA IMT showed stronger predictive ability for CHD and atherosclerotic disease than CCA IMT (odds ratios of 1.36 and 1.35, respectively).
Structured PICO
Does intima-media thickness (IMT) of the internal carotid artery correlate better with prevalent coronary heart disease and atherosclerotic disease than common carotid artery IMT in older adults?
P
Population
5117 adults aged 65 years or more enrolled in the Cardiovascular Health Study
I
Intervention
Measurement of intima-media thickness (IMT) of the common carotid arteries (CCA) and internal carotid arteries (ICA) using duplex ultrasound
O
Outcome
Association of CCA IMT and ICA IMT with prevalent coronary heart disease (CHD), clinically manifest atherosclerotic disease (ASD), and major risk factorssurrogate
Internal carotid artery intima-media thickness is a stronger correlate of prevalent coronary heart disease and atherosclerotic disease than common carotid artery intima-media thickness in older adults.
Cite This Study
O’Leary et al. (1996) studied this question.