Key result
New common carotid plaque progression is linked to ~95% higher incident CVD risk.
Why the study?
Does the progression of intima-media thickness and incident common carotid artery plaque increase the risk of incident cardiovascular disease in individuals without baseline CVD?
Population
4724 participants without cardiovascular disease at baseline, mean age 59.7±11.9 years, from the Suita Study.
Comparison
Progression of intima-media thickness and… vs No progression of IMT or no incident CCA plaque.
Design
Cohort
Follow-up
Up to December 2013 (59,909 person-years)
Authors
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Progression of incident carotid plaque signals higher CVD risk in primary prevention; extends prior cohorts but leaves clinical utility of monitoring open.
Cohort (n=4,724)
Does the progression of intima-media thickness and incident common carotid artery plaque increase the risk of incident cardiovascular disease in individuals without baseline CVD?
Effect estimate: HR 1.95 (95% CI 1.14-3.30)
Kokubo et al. (2018) conducted a cohort in Without cardiovascular disease at baseline (n=4,724). Incident common carotid artery (CCA) plaque vs. No incident CCA plaque was evaluated on Incident cardiovascular disease (CVD) (HR 1.95, 95% CI 1.14-3.30). New progression of incident common carotid artery plaque was associated with a significantly increased risk of incident cardiovascular disease (HR 1.95; 95% CI 1.14-3.30).
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