Key result
Carotid plaque (CIMT ≥ 1.5 mm) was associated with an increased risk of CV death, MI, stroke, or CV hospitalization compared to the lowest CIMT quartile (HR 1.73; 95% CI 1.31-2.27; p=0.0001).
Why the study?
Does the presence of carotid plaque or increased carotid intima-media thickness predict future cardiovascular ischemic events in patients with pre-existing atherosclerotic vascular disease?
Cohort (n=2,317)
Does the presence of carotid plaque or increased carotid intima-media thickness predict future cardiovascular ischemic events in patients with pre-existing atherosclerotic vascular disease?
Hazard Ratio: 1.73 (95% CI 1.31–2.27)
p-value: p=0.0001
The presence of carotid plaque (CIMT ≥ 1.5 mm), rather than just the thickness of the intima-media, is significantly associated with an increased risk of cardiovascular morbidity and mortality in patients with established atherosclerotic vascular disease.
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May aid risk stratification in established vascular disease; extends observational data but leaves open prospective validation.
Keo et al. (2011) conducted a cohort in Atherosclerotic vascular disease (n=2,317). Carotid plaque (CIMT ≥ 1.5 mm) vs. Lowest CIMT quartile was evaluated on Quadruple endpoint (CV death, myocardial infarction, stroke, hospitalization for CV events) (HR 1.73, 95% CI 1.31-2.27, p=0.0001). Carotid plaque (CIMT ≥ 1.5 mm) was associated with an increased risk of CV death, MI, stroke, or CV hospitalization compared to the lowest CIMT quartile (HR 1.73; 95% CI 1.31-2.27; p=0.0001).
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