Key result
Each 10 μm/y reduction of cIMT progression by interventions resulted in a relative risk for cardiovascular disease of 0.91 (95% CrI 0.87-0.94).
Why the study?
The study was conducted to quantify the association between the effects of interventions on carotid intima-media thickness progression and their effects on cardiovascular disease risk.
Does the reduction of carotid intima-media thickness (cIMT) progression predict a reduction in cardiovascular disease (CVD) risk?
Population
100 667 patients across 119 randomized controlled trials
Comparison
Interventions affecting cIMT progression vs control
Design
Bayesian meta-regression of randomized controlled trials
Follow-up
Average follow-up of 3.7 years
Authors
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Supports cIMT progression as a valid surrogate endpoint; confirms its utility for evaluating CVD risk reduction in trials.
Meta-Analysis (n=100,667)
Yes
Does the reduction of carotid intima-media thickness (cIMT) progression predict a reduction in cardiovascular disease (CVD) risk?
Relative Risk: 0.91 (95% CI 0.87–0.94)
Reductions in carotid intima-media thickness progression significantly predict reductions in cardiovascular disease risk, supporting its use as a surrogate marker in clinical trials.
Willeit et al. (2020) conducted a meta-analysis in Cardiovascular disease (n=100,667). Reduction of cIMT progression (per 10 μm/y) was evaluated on Combined CVD end point (myocardial infarction, stroke, revascularization procedures, or fatal CVD) (RR 0.91, 95% CI 0.87-0.94). Each 10 μm/y reduction of cIMT progression by interventions resulted in a relative risk for cardiovascular disease of 0.91 (95% CrI 0.87-0.94).
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