Key result
Increased carotid intima media thickness is associated with increased cardiovascular disease risk but lacks meaningful incremental prognostic value over standard clinical risk algorithms.
Why the study?
Does reduced carotid intima media thickness progression predict cardiovascular risk reduction?
Carotid intima-media thickness (cIMT) assessment does not provide meaningful incremental prognostic value for cardiovascular risk beyond standard clinical risk prediction algorithms.
-mode ultrasound assessment of extracranial carotid artery morphology was first shown to predict cardiovascular disease (CVD) risk, specifically acute myocardial infarction, by Salonen and Salonen in 1991. Since then, a number of studies have shown that increased cIMT, most commonly measured in the common carotid artery, is associated with increased CVD risk. The major determinants of cIMT appear to be genetic factors and vascular disease-related risk factors, especially advancing age and hypertension. Several studies have also shown that cIMT essentially lacks meaningful incremental prognostic value over and above the Framingham or other clinical risk prediction algorithms. 2-5 6][7]
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Prediman K. Shah (2020) conducted a review in Cardiovascular disease risk. Carotid Intima Media Thickness (cIMT) was evaluated on Cardiovascular disease (CVD) risk. Increased carotid intima media thickness is associated with increased cardiovascular disease risk but lacks meaningful incremental prognostic value over standard clinical risk algorithms.
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