November 1, 1992Journal of Magnetic Resonance Imaging
Cardiac metabolism in patients with dilated and hypertrophic cardio‐myopathy: Assessment with proton‐decoupled P‐31 MR spectroscopy
Why the study?
Does proton-decoupled P-31 MR spectroscopy detect abnormalities in cardiac metabolism in patients with dilated and hypertrophic cardiomyopathy compared to healthy subjects?
Population
26 subjects including healthy controls, patients with dilated cardiomyopathy, and patients with hypertrophic…
Comparison
Proton-decoupled phosphorus-31 MR spectroscopy vs Healthy control subjects
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
May aid metabolic phenotyping in HCM; leaves open prognostic or therapeutic utility.
Structured PICO
Does proton-decoupled P-31 MR spectroscopy detect abnormalities in cardiac metabolism in patients with dilated and hypertrophic cardiomyopathy compared to healthy subjects?
P
Population
26 subjects including healthy controls (n=9), patients with dilated cardiomyopathy (DCM, n=9), and patients with hypertrophic cardiomyopathy (HCM, n=8).
I
Intervention
Proton-decoupled phosphorus-31 (P-31) MR spectroscopy
C
Comparator
Healthy control subjects
O
Outcome
Cardiac metabolism parameters including phosphocreatine (PCr)-to-adenosine triphosphate ratio, myocardial pH, and Pi/PCr ratiosurrogate
Proton-decoupled P-31 MR spectroscopy can detect metabolic abnormalities, including altered PCr/ATP ratios and myocardial pH, in patients with hypertrophic and dilated cardiomyopathy.
Cite This Study
Roos et al. (1992) studied this question.