Metronidazole and cefuroxime concentrations in tunnelized facial artery myomucosal island flaps.

Key Points

• To evaluate the concentrations of metronidazole and cefuroxime in tunnelized facial artery myomucosal island flaps.
• Measured antimicrobial concentrations at two different minimum inhibitory concentrations (MIC), 2 µg/mL and 4 µg/mL.
• Assessed tissue exposure effectiveness in relation to flap necrosis in patients.
• MIC ratios varied from 120-151 at 2 µg/mL and 60-76 at 4 µg/mL.
• The patient with complete flap necrosis had the lowest antibiotic exposure.
• Standard dosing of cefuroxime and metronidazole was effective against oral cavity pathogens.