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Assesses antibiotic dosing effectiveness for infection control in oral cavity flaps, suggesting adequate tissue exposure for pathogens.
/MIC ratios were 120-151 at MIC 2 µg/mL and 60-76 at MIC 4 µg/mL. The lowest exposures occurred in the single patient with complete flap necrosis. Despite altered pharmacokinetics in tunnelized FAMM island flaps, standard perioperative dosing of cefuroxime and metronidazole provides adequate tissue exposure for typical oral cavity pathogens.
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Hanberg et al. (2026) studied this question.
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