Key result
Perioperative prophylaxis with single-dose oral ciprofloxacin and IV metronidazole yielded a 3% wound infection rate, significantly lower than the 13.4% rate with the historical gentamicin regimen.
Why the study?
Does single-dose oral ciprofloxacin plus IV metronidazole reduce wound infection rates compared to a historical gentamicin plus metronidazole regimen in adults undergoing elective colorectal surgery?
RCT (n=818)
Randomized to 1, 2, or 3 hours before anesthesia
Does single-dose oral ciprofloxacin plus IV metronidazole reduce wound infection rates compared to a historical gentamicin plus metronidazole regimen in adults undergoing elective colorectal surgery?
Absolute Event Rate: 3% vs 13.4%
A single oral dose of ciprofloxacin combined with IV metronidazole provides highly effective perioperative antibiotic prophylaxis for colorectal surgery, with lower wound infection rates than a historical gentamicin-based regimen.
No takes yet. Share an insight, caveat, or question.
Single-center observational prophylaxis data; leaves open need for randomized trials versus modern regimens.
Rohwedder et al. (2009) conducted an RCT in Elective colorectal surgery (n=818). Oral ciprofloxacin plus intravenous metronidazole vs. Intravenous gentamicin plus intravenous metronidazole was evaluated on Wound infection. Perioperative prophylaxis with single-dose oral ciprofloxacin and IV metronidazole yielded a 3% wound infection rate, significantly lower than the 13.4% rate with the historical gentamicin regimen.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: