Key result
Oral ciprofloxacin plus metronidazole significantly reduced postoperative wound infections and other infective complications compared to gentamicin plus metronidazole (P<0.02).
Why the study?
Does oral ciprofloxacin plus metronidazole reduce postoperative wound infections in patients undergoing colorectal surgery compared to gentamicin plus metronidazole?
RCT (n=169)
Does oral ciprofloxacin plus metronidazole reduce postoperative wound infections in patients undergoing colorectal surgery compared to gentamicin plus metronidazole?
p-value: p=<0.02
Oral ciprofloxacin plus metronidazole offers advantages in efficacy and ease of administration compared with parenteral antibiotics for prophylaxis in colorectal surgery.
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Oral ciprofloxacin may reduce infections after colorectal surgery; leaves open need for confirmatory trials on optimal regimens.
McArdle et al. (1995) conducted an RCT in Colorectal surgery (n=169). Oral ciprofloxacin plus metronidazole vs. Gentamicin plus metronidazole was evaluated on Postoperative wound infections and other infective complications (p=<0.02). Oral ciprofloxacin plus metronidazole significantly reduced postoperative wound infections and other infective complications compared to gentamicin plus metronidazole (P<0.02).
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