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May 4, 2026

Cross-tissue atlas of mucosa-associated lymphoid tissue lymphomas reveals intratumoral heterogeneity and microenvironmental subtypes.

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Authors

KKKai KangYWYan WuXSXia Sun

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Overview

Randomized trial analyzes lymphoma microenvironment, revealing diverse subtypes and therapeutic vulnerabilities.

Key Points

  • This research investigates the microenvironmental heterogeneity of MALT lymphoma and identifies subtypes with distinct therapeutic implications.
  • Profiled 89 MALT lymphoma samples using bulk, single-nucleus, and spatial RNA sequencing.
  • Conducted integrative analysis of 120 bulk transcriptomes across multiple cohorts with single-nucleus data.
  • Mapped cellular compositions and interaction networks via single-cell and spatial techniques.
  • Identified three LME subtypes: mesenchymal, inflammatory, and depleted.
  • Demonstrated distinct interactions related to B cell activation and angiogenesis across subtypes.
  • Established an LME-based classification framework with biological and clinical relevance.

Cite This Study

Kang et al. (2026) studied this question.

synapsesocial.com/papers/69f8380b3ed186a73998261bhttps://doi.org/10.1016/j.xcrm.2026.102785
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