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December 8, 2025BloodOpen Access

Multi-dimensional transcriptomic profiling reveals novel tumor microenvironment landscape and subtype-specific therapeutic Vulnerabilities of MALT lymphomas

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Authors

KKKai KangYYYuqi YangAZAilin Zhao

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Overview

Multi-dimensional profiling reveals tumor microenvironment characteristics in MALT lymphomas, highlighting therapeutic targets and responses to agents.

Key Points

  • To characterize the tumor microenvironment of MALT lymphomas and identify subtype-specific therapeutic vulnerabilities.
  • Collected bulk RNA, single-nucleus, and spatial transcriptomic sequencing data from various sites
  • Employed non-negative matrix factorization to classify tumor microenvironment subtypes
  • Conducted drug sensitivity analyses based on identified subtypes
  • Identified three tumor microenvironment subtypes: Mesenchymal, Inflammatory, and Depleted
  • Mesenchymal subtype showed sensitivity to anti-angiogenic agents, while Depleted subtype responded to cell cycle-targeting therapies
  • Highlighted potential therapeutic targets like Treg cells and angiogenesis-promotion mechanisms in the Mesenchymal subtype

Cite This Study

Kang et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d966https://doi.org/10.1182/blood-2025-1751
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cross-tissue atlas of mucosa-associated lymphoid tissue lymphomas reveals intratumoral heterogeneity and microenvironmental subtypes.2026
  2. 2Single-nucleus dissection of peripheral T-cell lymphomas reveals distinct microenvironmental ecosystems and therapeutic vulnerabilities2025
  3. 3Abstract A056: Microenvironmental ecosystems in peripheral T-cell lymphomas reveal therapeutic vulnerabilities2026
  4. 4Abstract PR05: Single-cell transcriptomics reveals shared and subtype-specific vulnerabilities of the tumor-microenvironment ecosystems in peripheral T-cell lymphomas2024
  5. 5Abstract A049: Spatially resolved microenvironment profiling reveals distinct follicular lymphoma archetypes2026