Secular Trends in Precocious Puberty: Increasing Prevalence and Obesity Effect in the Western Black Sea Region

July 23, 2025

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Key Points

This study analyzes the prevalence of precocious puberty and associated factors in the Western Black Sea region during and after the COVID-19 pandemic.
Retrospective evaluation of 270 patients diagnosed with precocious puberty from May 2021 to April 2024.
Comparison of patients across two periods: early normalization (Group 1) and late post-restrictions (Group 2).
Logistic regression used to analyze factors associated with treatment necessity.
75.8% of patients were diagnosed with central precocious puberty.
53.1% of Group 1 patients presented at an advanced Tanner stage (≥3) compared to 14% in Group 2 (p = 0.001).
Treatment was necessary for 58.3% of Group 1 patients with CPP or rapidly progressive puberty, versus 21.2% in Group 2.

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Retrospective analysis examines precocious puberty prevalence across pandemic periods, revealing significant trends.

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Bilici et al. (2025) studied this question.

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