Key result
The COVID-19 lockdown was associated with a significantly higher incidence of central precocious puberty in girls compared to the previous two years (4.6% vs 0.41%, p < 0.001).
Why the study?
The study was conducted to evaluate the incidence of central precocious puberty during the COVID-19 lockdown compared with the previous 2 years.
Does the COVID-19 lockdown increase the incidence of central precocious puberty in girls?
Observational (n=37)
Yes
Does the COVID-19 lockdown increase the incidence of central precocious puberty in girls?
Absolute Event Rate: 4.6% vs 0.41%
p-value: p=<.001
The COVID-19 lockdown was associated with a significantly increased incidence of central precocious puberty in girls, likely driven by increased adiposity and lifestyle changes.
May warrant closer monitoring of pubertal timing in girls; leaves open causal mechanisms and need for prospective confirmation.
To evaluate retrospectively the incidence of central precocious puberty (CPP) during the COVID 19 lockdown and comparing the data with the corresponding data from the previous 2 years. The study included 23 girls with CPP and 14 patients with early puberty. Nineteen patients were newly diagnosed with CPP compared to 4 patients diagnosed with CPP during the previous 2 years. The number of new patients diagnosed with CPP was significantly higher than the mean during the previous 2 years ( P < .001). There were more overweight patients with CPP during and after the lockdown ( P < .05). These patients had also increased uterus length ( P < .05) and more advanced bone age ( P < .05). The increase in the incidence of central precocious puberty during and after the lockdown due to COVID 19 can be considered a serious consequence of the increased fat mass and an early indicator of the worsening of childhood obesity.
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Itani et al. (2022) conducted an observational in Central precocious puberty and early puberty (n=37). COVID-19 lockdown vs. Pre-lockdown period (previous 2 years) was evaluated on Incidence of central precocious puberty among referred patients (p=<.001). The COVID-19 lockdown was associated with a significantly higher incidence of central precocious puberty in girls compared to the previous two years (4.6% vs 0.41%, p < 0.001).
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