Why the study?
The relationship between radiation doses to the coronary arteries and the location of coronary stenosis requiring intervention after 3DCRT for breast cancer needed to be assessed.
Does higher radiation dose to the mid LAD increase the risk of coronary stenosis requiring intervention in breast cancer survivors?
Does higher radiation dose to the mid LAD increase the risk of coronary stenosis requiring intervention in breast cancer survivors?
High radiation doses (>20 Gy) to the mid LAD during breast cancer radiotherapy significantly increase the risk of subsequent coronary stenosis requiring intervention in that specific arterial segment.
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High mid-LAD doses may warrant planning constraints in breast RT; leaves open prospective confirmation of causality.
Wennstig et al. (2019) studied this question.
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