BACKGROUND: Ga-FAPI PET/CT for early and precise lesion characterization. METHODS: Ga-FAPI PET/CT. RESULTS: The study included 121 female patients with a mean age of 53.8 ± 12.2 years (18-80 years). A total of 184 adnexal lesions with abnormal uptake were identified. Pathology/follow-up confirmed 82.6% as malignancies, comprising 84 primary and 16 metastatic cases. Additionally, 2 borderline tumors and 19 benign lesions were detected. The positive predictive value was 83.5%. SUVmax differed significantly among primary malignant, metastatic, and benign lesions (12.52 ± 5.41 vs. 9.78 ± 3.39 vs. 5.52 ± 4.17). In the subset of patients with available pathological specimens, SUVmax showed weak to moderate positive correlations with Ki-67 (r = 0.361, p 20% group was significantly higher than in the Ki67 ≤ 20% group (p < 0.001). ROC analysis showed an AUC of 0.85 of SUVmax alone for diagnosing malignant adnexal lesions, increasing to 0.89 when combined with tumor markers. DISCUSSION: Ga-FAPI PET/CT demonstrates high diagnostic performance for ovarian lesions. Among pathologically confirmed cases, SUVmax correlates with proliferative activity and malignant potential, supporting its role in diagnostic optimization.
Wang et al. (Sat,) studied this question.
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