Answers are grounded in this paper and cite their sources.
Reveals AscB catalyzes unique fused cyclophane formation in precursor peptides, indicating novel enzymatic activity.
sp. HM5-17, that can catalyze the cross-linking between Tyr-C3 and Trp-N1, as well as the hydroxylation at Trp-C5 in the YxWxH motif. However, only AscB was able to catalyze the formation of a second cyclophane between Trp-C4 and His-Nτ, generating a fused cyclophane in the YxWxH motif. This is the first report of an enzyme that can catalyze such cross-linking in RiPPs.
No takes yet. Share an insight, caveat, or question.
Haedar et al. (2026) studied this question.
Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context: