Why the study?
The contribution of microtubules to cardiomyocyte membrane Young's modulus is understudied and has not been interrogated in the context of myocardial infarction or mechanical loading and unloading.
Microtubule posttranslational modifications regulate cardiomyocyte stiffness, with acetylation providing flexibility and detyrosination imparting rigidity, which may impact cardiac mechanics following myocardial infarction.
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May influence post-MI cardiac stiffness in rodents; hypothesis-generating for microtubule-targeted therapies in humans.
Swiatlowska et al. (2020) studied this question.
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