Key result
Decreased myocyte contractile function in congestive heart failure may involve alterations in calcium handling, myofilament function, and the cytoskeleton.
This review highlights that alterations in calcium handling, myofilament function, and the cytoskeleton contribute to decreased myocyte contractile function in heart failure.
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May inform targeted HF therapies; leaves open clinical translation of these pathways.
Pieter P. de Tombe (1998) conducted a review in Congestive heart failure. Decreased myocyte contractile function in congestive heart failure may involve alterations in calcium handling, myofilament function, and the cytoskeleton.
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